Warfarin complications higher in practice

The finding bolsters the case for listing newer anticoagulants on the PBS, they say.

A Canadian population-based cohort study of 125,195 patients with atrial fibrillation aged 66 or older, who started warfarin between 1997 and 2008, found the rate of haemorrhage was highest in the first month after treatment initiation.

The overall risk of haemorrhage over the 13-year period was 3.8% per person-year but was 11.8% in the first 30 days. For those over 75, the overall risk was 4.6%, compared to 2.9% for younger people.