Age-related macular degeneration linked to aspirin use

University of Sydney-led researchers analysed the aspirin use, cardiovascular disease and other AMD risk factors among almost 2400 participants older than 49 who were enrolled in the Blue Mountains Eye Study, performing five-year follow-ups over a 15-year period.

In the group, more than one in 10 participants (257) were regular aspirin users, defined as using the drug once or more per week. One-quarter developed wet AMD by the end of the study period.

The researchers found that after 15 years, regular aspirin users were almost 2.5 times more likely to develop AMD than non-regular aspirin users.

The authors also noted the risk of AMD accumulated with time, and that rates of neovascular AMD were 0.8% among non-regular aspirin and 1.9% in regular users after a five-year follow-up.

“The increased risk of neovascular AMD was detected only after 10 or 15 years, suggesting that cumulative dosage is important