Alzheimer’s has 25-year onset: study

Researchers from Australia, the UK and US have constructed a timeline of the disease following a prospective, longitudinal study of 128 people with genetic risk as they were in a family with a known mutation for autosomal dominant Alzheimer’s disease.

They found that concentrations of amyloid-beta in cerebro-spinal fluid began to drop about 25 years before people were expected to get symptoms, and amyloid plaque deposits in the brain can be seen about 15 years before symptoms.

In addition, increased concentrations of tau protein can be measured in CSF, and brain atrophy is