Amputation risk lower with statins

The retrospective cohort study of 84,000 patients from a Veterans Affairs database showed that statin users were 35% less likely to have a lower extremity amputation than those who did not use cholesterol-lowering agents.

Treatment failure, defined as lower extremity amputation or death, was 43% less likely in statin users.

Use of other cholesterol-lowering agents, including fibrates and nicotinic acid, did not decrease amputation but did improve survival.

The results were adjusted for age, comorbidities and HbA1c.

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