Amputations linked to diabetes drug

The PBS-listed type-2 diabetes drug, canagliflozin, has been linked to an increase in leg and foot amputations, mostly affecting the toes.

The sodium-glucose co-transporter-2 inhibitor is sold in Australia under the brand name Invokana.

The US Food and Drug Administration is investigating the potential problem after an interim analysis from the clinical trials found roughly twice the risk for leg

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