Anaesthesia and dementia risk

Comparing 25,000 patients from a national database who underwent anaesthesia and surgery with 100,000 controls, the anaesthesia group’s risk of dementia was twofold higher, after adjusting for hypertension, hyperlipidaemia, depression and comorbidities.

People with vascular dementia were excluded, to control for dementia occurring as a result of perioperative events.

The risk of dementia was highest in those who received regional anaesthesia, followed by intravenous or intramuscular, and general anaesthesia.