Antidepressant value in back pain remains unclear

But it's still an option worth considering in some patients, says researcher

Low-dose amitriptyline does not have clear benefits for patients with chronic low-back pain that has no specific cause, according to a randomised clinical trial by Monash University researchers.

Despite the lack of evidence that antidepressants are more effective than placebo for low-back pain, seven of 14 national and international guidelines recommend their use in this setting.

Researchers from Monash University in Melbourne investigated whether low-dose amitriptyline (25mg per day) was effective in reducing pain, disability and work absence

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