Antidepressants blamed for weight regain

After adjusting for confounding factors, depressive symptoms were not associated with weight regain but antidepressants were.

Participants who had been using antidepressants at the visit six months prior had 72% higher risk of weight regain than those who were not using antidepressants. That association remained even when the analysis was restricted to SSRI antidepressants (which accounted for 78% of all the antidepressants participants used).

By about the five-year mark, 57% of those who