Antihypertensives linked to fetal abnormalities

The TGA said in one case fetal death occurred at 34 weeks, seven weeks after ceasing candesartan. In other cases the fetuses were diagnosed with renal failure, kidney malformation, nephrocalcinosis or congenital genitourinary system abnormalities.

In a safety update, the TGA said it had a total of four reports, including three from 2011, of abnormalities following candesartan use, and had similar reports linked to use of irbesartan, enalapril, lisinopril, perindopril and captopril during pregnancy.

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