Aspirin coating could reduce absorption

The study of 400 healthy adults set out to find the prevalence of true pharmacological resistance to aspirin that could be explained by genetic causes.

While estimates of resistance vary from 5% to 20% in most studies, the authors from the University of Pennsylvania said they failed to identify a single case of true aspirin resistance.

“By contrast, pseudo-resistance, due to delayed and reduced drug absorption was common after ingestion of enteric coated aspirin,” they said.

Participants were screened for their response to a single oral dose of 325mg immediate release or enteric