Atypical antipsychotic use linked to nocturnal enuresis

ONE in five patients taking clozapine experiences enuresis, a significantly higher rate than for other atypical antipsychotics, a study shows.

Researchers from New Zealand, presenting data at the recent RANZCP congress, compared nocturnal enuresis in adult patients taking clozapine, risperidone, olanzapine and quetiapine in an observational cohort study.

Patients taking atypical antipsychotics were followed up with questionnaires given by their doctors who asked the patients about bedwetting.

They found that 20% of the 82 patients taking clozapine experienced enuresis, compared with 9% of the 115 taking olanzapine, 7% of the 105 taking quetiapine, and 6% of the 195 taking risperidone.

Compared to clozapine, the risk of nocturnal enuresis in patients taking olanzapine was 59% lower, 72% lower for quetiapine, and 75% lower for risperidone.

Dr Mira Harrison-Woolrych, director of intensive medicines monitoring in the department of