Avoid PPIs in infants with reflux

Answer: Use of PPIs in infants with gastro-oesophageal reflux is not supported by evidence, as they do not reduce associated symptoms.

Crying, irritability and vomiting are common in infants in the first few months of life. Symptoms of normal infant reflux are often incorrectly attributed to GORD. GORD is indicated by troublesome symptoms such as frequent regurgitation and persistent feeding difficulties, and can sometimes result in failure to thrive, haematemesis, chronic respiratory disorders and oesophagitis.1