Beware this benign biopsy

Patients with a solitary red or purple non-scaly skin lesion need close monitoring if a biopsy is reported as a benign lymphocytic infiltrate.

In the early stages it can be difficult for a pathologist to be certain the process is benign. Special studies can see if the lymphocyte infiltrate is polyclonal, suggesting a benign lesion, or monoclonal, suggesting malignancy.

This lesion was initially pronounced benign, but within a year numerous other lesions appeared on the lower leg and the condition was ultimately diagnosed as a large cell B cell lymphoma, leg type with a poor prognosis.

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