Beware gastroenteritis risk with PPIs, doctors told

Doctors need to be aware of a higher risk of gastroenteritis when prescribing PPIs, say Australian researchers.

Data from nearly 40,000 people in the 45 and Up study showed a 70% increased risk of hospitalisation for infectious gastroenteritis in people using PPIs.

There was a dose–response relationship, with those on the highest doses more than doubling their risk of gastroenteritis compared with non-users.

People with chronic bowel problems were more likely to be on PPIs and were also at greatest risk of a gastro hospitalisation, the researchers from the ANU