Bisphosphonate compliance linked to increase in femoral fractures

Elderly women who take bisphosphonates long-term have an increased risk of atypical femur shaft fractures, a large international study confirms, but the overall benefits of treatment still outweigh the risks.

The study of over half a million postmenopausal women found that each additional year of bisphosphonate treatment showed a progressive increase in subtrochanteric/femoral shaft fractures.

This was in contrast to a steady reduction in the rate of intertrochanteric/femoral neck (IT/FN) fractures, found the authors from