Botox twice as effective as anticholinergics for incontinence

In a trial of 241 women, one group was randomised to receive six months of oral medication plus a saline injection while the other arm received one injection of botulinum toxin-A plus daily oral placebo.

The anticholinergic therapy and botulinum toxin-A injections led to similarly reduced daily episodes of urgency incontinence (from an average of five per day to just over three per day).

However 27% of women receiving botulinum toxin-A reported complete resolution of symptoms compared to 13% on the medication.