Call for caution on PPIs
PROTON pump inhibitors should be prescribed at the lowest dose and for the shortest possible duration because of potential side effects, researchers say.
Use of the drugs has expanded beyond the evidence base, putting patients at increased risk of adverse events, they warn.
The treatment has been associated with rebound heartburn after discontinuation, malabsorption of vitamin B12, iron and magnesium, an increased risk of infection with Clostridium difficile and possible increased risk of fractures in patients.
“PPIs should be used with