Causes of chronic cough
Children are increasingly becoming colonised with methicillin-resistant Staphylococcus aureus (MRSA) and some develop acute invasive respiratory disease such as necrotising pneumonia and empyema.
Over the past decade, this colonisation in airway secretions is found to be more likely in hospital and in children with abnormal airways, such as those with cystic fibrosis (CF), or with neurocognitive impairment, who often have recurrent pulmonary aspiration.
Many people had presumed that MRSA found in the sputum of those with cystic fibrosis was more of a passenger than a pathogen. However, a large review from the US cystic fibrosis database has suggested otherwise.
In a study to determine whether children and adults with CF who acquired MRSA had increased mortality, the files of 19,833 MRSA-negative subjects aged 6–45 years were followed between 1996 and 2008. Somewhat surprisingly, 5759