Caution urged for cannabidiol in epilepsy

Cannabidiol and AED combinations need to be carefully managed as they could give rise to adverse drug reactions, US researchers say.

An open-label study of 81 paediatric and adult patients found valproate and cannabidiol was linked to impaired liver function and over-sedation. Four children discontinued their medication, which led to improved liver function.

Cannabidiol also had drug-to-drug interactions with topiramate and rufinamide