Chemotherapy affects cognition in older women

A gene may worsen cognitive decline after systemic therapy for breast cancer

Older women who have had chemotherapy for breast cancer are at increased risk of cognitive decline compared with their peers, but genetics plays an important role, a US study shows.

In the Thinking and Living with Cancer study, nearly 350 women over 60 with newly diagnosed non-metastatic breast cancer were matched one-to-one with healthy controls.

Cognitive function was tested at baseline and at one- and two-year follow-up.

While healthy controls and breast cancer patients who had not had