Chronic pain warps personalities

Chronic neuropathic pain can alter individual personalities through changes in the brain, according to Australian researchers.

Their study led by Dr Sylvia Gustin of the Neuroscience Research Institute shows chronic pain is associated with changes in the medial prefrontal cortex (mPFC), anterior cingulate cortex (ACC) and mediodorsal thalamus.

The changes in these brain regions are significantly correlated with the personality temperament of novelty-seeking.

Chronic pain patients also lack the temperament persistence, which has been associated with an overlapping circuit including