Colchicine safe in pregnancy: systematic review

Taking colchicine in pregnancy does not put women at higher risk of miscarriage or fetal malformations, according to an Australian systematic review and meta-analysis.

The finding is most pertinent for women with familial Mediterranean fever (FMF), who are recommended to take the medicine for life to prevent systemic amyloidosis and the risk of subsequent renal failure, say the study authors.

Because colchicine crosses the placenta, inhibits mitosis and has teratogenic effects in animals at high doses, it is classified as a category D drug: “suspected …to cause an increased