CV events concern with bupropion

The TGA announced today that it was updating the product information for bupropion (Clorprax, Prexaton and Zyban SR) to recommend doctors exercise care when using these products with patients with pre-existing hypertension or those also using nicotine patches. 

“There have been reports of patients receiving bupropion (alone and in combination with nicotine replacement therapy) experiencing severe hypertension requiring acute treatment, in patients both with and without pre-existing hypertension,” said the TGA in its Medicines Safety Update

Bupropion has been linked to 24 reports of myocardial infarction, five reports of cerebrovascular accident and one report of transient ischaemic attack up to July 2014.

GPs are advised to perform weekly blood pressure monitoring for patients using both nicotine patches and bupropion, and to consider