Depression link to hypoglycaemic risk

The longitudinal cohort study in 4000 patients followed for five years showed that depressed patients with diabetes had a 34% higher number of hypoglycaemic episodes and a 42% increased risk of having a severe hypoglycaemic episode compared with patients who were not depressed.

This increased risk of severe hypoglycaemic episodes may be due to poor self-care, failure to take medication, weight loss associated with comorbid depression, or psychobiologic changes associated with depression.

The effect was not modified by insulin treatment.

Ann Fam Med 2013; 11: 245–50