Dose-response demonstrated for weight loss in knee OA

Obese people with knee osteoarthritis are likely to gain significantly more benefits if they manage to lose up to 20% of their body weight, a study suggests.

Researchers, including Professor David Hunter of the University of Sydney, performed a post-hoc analysis of data from 240 obese adults with pain from knee osteoarthritis who were participating in the 18-month Intensive Diet and Exercise for Arthritis (IDEA) trial.

Most (72%) of the participants were women, the average age was 66 years, and the average BMI at baseline was 33kg/m2.

Participants who lost 10% or more of their baseline body