Dyslipidaemia linked to increased risk of Alzheimer’s pathology

DYSLIPIDAEMIA is associated with an increased risk of developing Alzheimer’s disease-related brain pathology, researchers have found in a population-based study.

Japanese researchers demonstrated the link in a study where they measured lipids in a cohort of men and women who were then followed for up to 15 years, with 34% developing dementia.

The study involved examination of brain specimens from 147 members of the cohort who died between 1998 and 2003, and compared the findings with their measures of cholesterol and  triglycerides taken in 1988.

The researchers found that adjusted means of total cholesterol (TC), LDL cholesterol (LDLC), LDL/HDL cholesterol and non-HDL cholesterol were significantly higher in subjects who had neuritic plaques on autopsy.

Subjects in the highest lipid quartiles had significantly higher risks of plaques compared to those in the lowest quartiles, suggesting a threshold effect, the researchers said.