Earlier menopause awaits women who survive childhood cancer

French researchers used questionnaires to follow up a cohort of 1109 survivors, of whom 32% had reached 40 years of age.   

Among 97 women reaching menopause, the average age was 44 years compared to 52 years in the overall European population.

Women treated with alkylating agents and a low dose of radiation to the ovaries after the onset of puberty were 29 times more likely to experience non-surgical menopause. 

“This study provides data on risk factors for a reduced fertility window in order to inform survivors at risk and help oncologists to design new therapeutic