Early warfarin resumption cuts patient mortality
In a US study of 442 patients, 260 (59%) resumed warfarin, including 41 who never stopped treatment. Median time to resumption was four days.
Of those resuming warfarin, one had a thrombotic event compared with 10 of 182 patients not resuming warfarin in the 90-day follow-up period.
There were 26 recurrent GI bleeds and 15 deaths in those resuming warfarin compared to 10 GI bleeds and 37 deaths in those who did not.
Patients who never interrupted warfarin or who resumed therapy within 14 days experienced no