Efficacy of antidepressants in fibromyalgia

A: Fibromyalgia syndrome is a common chronic condition. In addition to pain, patients have other problems, such as fatigue and poor sleep. Patients with fibromyalgia often have a reduced quality of life.

There have been several trials of antidepressant drugs as a treatment for fibromyalgia. A German group has now reviewed these studies.

From 337 citations, the group selected 34 studies. These were further reduced to 18 randomised placebo-controlled trials.

Most of the trials were for 12 weeks or less. Treatment was completed by 1427 patients of whom 916 took