A retrospective observational study that tracked 351 US residents who have lived with type 1 diabetes for 50 years has found that significant numbers escaped many of the most common complications – and good glucose control wasn’t the only defining factor.
About 43% of the individuals remained free of diabetic retinopathy, 87% had no kidney disease, 39% had no neuropathy and just over 51% did not develop cardiovascular disease.
The study showed an association between complications and specific combinations of advanced glycosylation end products. Those with high plasma carboxyethyl-lysine and pentosidine were seven times more likely to have complications.
Diabetes Care 2011;34:968-974