Excess risk of cervical cancer remains after CIN treatment
A population-based cohort study conducted in the Netherlands between 1994 and 2006 found the residual risk was increased regardless of age or grade of neoplasia.
“These results have implications for women treated for CIN, although how the excess risk could be decreased is not straightforward,” the authors said.
They examined the incidence of cervical cancer among 38,956 women who returned for routine screening after completing cytological post-treatment follow-up with three consecutive normal smear test results. They compared the results to untreated women with normal cytology results.
The incidence rate was 35 per 100,000 woman years for those treated for CIN, compared to six per 100,000 for those with normal smear test results.
The authors said the risk was still low compared to observed rates of cervical cancer among those untreated for CIN 3, which was about 30% in 30 years.
“Our data probably point to high