Expert flags oestrogen-only HRT safer than combination

In an analysis of research – including the Million Women Study and the Women’s Health Initiative (WHI) study – published in Cancer Forum, Professor Olver said unopposed oestrogens had a better risk profile than oestrogen-progestogen combinations. A population health goal where the vast majority of HRT use was short-term unopposed oestrogens was highly desirable, he said.

“There are no data, for example, which would preclude prescribing short-term unopposed oestrogen HRT for a woman with severe symptoms of menopause, considering the low risk of adverse effects such as breast cancer balanced

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