First-line fertility treatment outdone in trial

Women with polycystic ovary syndrome are more likely to give birth if treated with letrozole than with clomiphene, according to trial results published in the New England Journal of Medicine.

The double-blind randomised trial involving 750 women showed that 27.5% of those treated with 2.5mg letrozole daily had live births, compared with 19.1% of those given 50mg a day of clomiphene, the first-line therapy.

The cumulative ovulation rate was higher with

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