First PSA test advised in mid-40s

The Swedish researchers used data from a case-controlled study in 22,000 men followed for 27 years to determine the best time to start PSA screening.

They found that 44% of prostate cancer deaths that occurred within 25–30 years of screening were in men in the highest 10th of PSA concentrations (≥1.6µg/L) at age 45–49, with the same proportion of deaths in the highest 10th at age 51–55.

However, in men aged 40 in the highest 10th of PSA concentrations, the risk of prostate cancer metastases was only 0.6% after 15 years of