Follow-up of adolescents with depression

Regardless of whether they received cognitive behaviour therapy, Prozac (Fluoxetine), both or placebo, participants who responded to treatment by the end of 12 weeks were less likely to abuse drugs.

Of those whose depression had receded after 12 weeks, 10% later developed a substance use disorder, compared with 25% of those who hadn’t responded to treatment within that timeframe.

Response to treatment did not reduce the chances of alcohol abuse, but alcohol disorder did predict depression recurrence.