Genes shape response to antidepressants
30th April 2013
A study of DNA from nearly 3000 patients taking antidepressants for up to 14 weeks showed that common single nucleotide polymorphisms (SNPs) explained 42% of the variance in antidepressant response.
The authors said the phenotype of antibody response is likely to be polygenic and involve a large number of SNPs with small effect sizes.
“The question of whether genetic markers can help predict response has major implications for personalising