Genes shape response to antidepressants

A study of DNA from nearly 3000 patients taking antidepressants for up to 14 weeks showed that common single nucleotide polymorphisms (SNPs) explained 42% of the variance in antidepressant response. 

The authors said the phenotype of antibody response is likely to be polygenic and involve a large number of SNPs with small effect sizes.

“The question of whether genetic markers can help predict response has major implications for personalising

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