Genotyping in rheumatology edges closer

Rheumatology is getting closer to being able to use genotyping to predict the severity of RA, mortality and response to treatment, the conference has heard. 

Dr Sebastian Viatte from the Arthritis Research UK Centre for Genetics and Genomics explained that previously a group of alleles on the HLA DRB1 gene, commonly known as the ‘shared epitope’, was thought to have the strongest effect on RA susceptibility.

But new research replicated in several cohort studies had now found evidence that the amino acid valine at position 11 of HLA-DRB1 (Val 11) was the strongest independent genetic

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