Glucose tolerance link to LV dysfunction
AN ORAL glucose tolerance test can help to identify patients with hypertension who have impaired diastolic function, a study suggests.
Researchers compared one-hour postload plasma glucose levels and diastolic function, assessed by standard echocardiography, in 120 patients with uncomplicated hypertension and normal glucose tolerance.
They found patients with a one-hour postload plasma glucose level of > 8.6 mmol/L had impaired left ventricular diastolic function compared with those with a level < 8.6 mmol/L.
The group with lower glucose levels also had lower left ventricular function mass index, left atrium volume and isovolumetric relaxation time.
Patients with normal glucose tolerance with a postload glucose level of 8.6 mmol/L or more had similar diastolic function to patients with impaired glucose tolerance and type 2 diabetes.
The authors said the findings indicated that modifications to left