Gout: wide range in allopurinol dose needed to treat-to-target

One patient was on 700mg/day

The allopurinol dose needed to bring serum urate to target in patients with gout varies widely and may be substantially above levels calculated on kidney function, a New Zealand study shows.

In a planned secondary analysis of data from an open-label clinical trial, researchers examined whether they could predict the allopurinol dose needed to bring a patient’s serum urate below a target level of 0.36 mmol/L (6mg/dL).

All 132 patients were not achieving target at baseline, despite being on the allopurinol dose calculated from their creatine clearance (CrCl), in