Gut receptors affect hyperglycaemia: study

Researchers from the University of Adelaide looked at expression of sweet taste receptors in 14 healthy subjects and 13 patients with T2DM under glycaemic clamp conditions.

Endoscopic biopsies showed transcript levels of one sweet taste receptor, T1R2, increased in both groups under euglycaemic conditions, but under hyperglycaemic conditions, T1R2 levels went down in healthy controls and increased in people with T2DM.

Defective regulation of T1R2 genes could enhance glucose absorption in these patients, the authors said.