High potency opioids no better for knee OA

NSAIDs, low and high potency opioids all have a similar effect on pain in knee osteoarthritis, according to a meta-analysis.

Data from 17 randomised trials of pharmacological treatments for knee OA found similar pain reductions on the WOMAC pain scale for all drug classes.

Significantly, high potency opioids such as hydromorphone and oxycodone performed no better than less potent ones such as tramadol.