High risk of microscopic colitis with PPIs, NSAIDs

Current and recent use of proton pump inhibitors and nonsteroidal anti-inflammatory drugs substantially ups the risk of microscopic colitis, Dutch researchers have confirmed.

Data from over 1200 cases of microscopic colitis with 6,000 matched controls showed current use of PPIs increased the odds of the condition by 3.37 times, compared with never use, while NSAIDs nearly doubled the risk.

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