HPV test triage beats smear

The analysis found triaging women with atypical squamous cells of undetermined significance (ASCUS) with high-risk HPV DNA testing was 27% more sensitive than a repeat smear for detecting cervical intraepithelial neoplasia (CIN)2+.

The study included more than 13,000 women with ASCUS across 39 studies, and showed the specificity of a repeat smear was nearly identical to the specificity of HPV testing for excluding CIN2+.

However, while HPV testing was 23% more sensitive than repeat cytology for