Hyperuricaemia may be an early marker of future diabetes
US researchers analysed 15-year follow-up data on 5012 young people aged 18–30 years who were diabetes-free at the time of enrolment.
On follow-up the incidence of diabetes and insulin resistance was higher among those with greater serum urate concentrations.
The authors noted that renal clearance of urate had been shown to be inversely related to the degree of insulin resistance.
Insulin resistance was associated with reduced nitric oxide and increased serum urate concentration reduced nitric oxide levels, the authors wrote.