Hypotension risk for CCB patients on macrolides

OLDER patients on calcium-channel blockers (CCBs) are at increased risk of hypotension if they take certain macrolides concurrently, a study shows.

The population-based crossover study of 7000 patients older than 66 years found those taking erythromycin while on CCBs had a sixfold higher risk of hospital admission for hypotension.

Taking clarithromycin with CCBs increased the risk nearly fourfold.

Doctors should be aware of the potential drug interaction due to the antibiotics potentiating CCBs by inhibiting cytochrome P450 enzymes, the authors said.

“Our findings highlight the consequences of an