IBS pain linked to defective immune response

Patients with IBS could have a defective immune response to pain due to decreased levels of opioid-producing macrophages, according to Australian research.

The researchers took peripheral blood mononuclear cell (PBMC) supernatants from more than 100 patients, with a 50-50 split between healthy subjects and those with IBS.

They applied these to the colorectal sensory afferent