Immune dysfunction link to schizophrenia

Post-mortem brain tissue from the dorsolateral prefrontal cortex of 37 people with schizophrenia was examined for changes in the expression of genes involved with immune function and compared to otherwise healthy controls.

The study, conducted by Neuroscience Research Australia, found increased levels of pro-inflammatory cytokines, which drive the activation of microglia, in 40% of people with schizophrenia.

Study author Professor Cyndi Shannon Weickert, Macquarie Group Foundation Chair of Schizophrenia Research at the University of NSW, said the findings