Ketamine no more effective than placebo to ease pain

Ketamine has been widely used off-label – at sub-anaesthetic doses – for management of chronic, complex cancer pain, although high level evidence to back its use has been limited to two under-powered trials, researchers said.

In a multi-site study involving 185 patients, researchers in the Palliative Care Clinical Studies Collaborative (PaCCSC) at Flinders University, Adelaide, found that ketamine administered subcutaneously with an escalating dose over five days had no different outcomes to placebo