Metformin not linked with acidosis in moderate CKD

Patients with type 2 diabetes and mild to moderate chronic kidney disease can take metformin without increased risk of acidosis, a large study suggests.

No increased incidence of hospitalisation for acidosis was seen across almost all levels of kidney function examined in a retrospective analysis comparing 48,000 patients taking metformin for type 2 diabetes with 27,000 patients who had T2DM but were not on the medication.

The exception was patients with an estimated glomerular filtration rate (eGFR) of below 30mL/min/1.73m2 who had double the risk of acidosis compared with similar patients not