Metformin in pregnancy linked to heavier children

Norwegian researchers randomised around 250 pregnant women with polycystic ovary syndrome (PCOS) to either a 2000mg daily dose of metformin or a placebo, from their first trimester of pregnancy to the birth of their child and followed them up a year after delivery.

Of the 200 women who responded to a follow-up questionnaire, the women who were on metformin lost less weight after delivery compared to the women on placebo.

“We believe that higher BMI one year after delivery can be attributed to a rebound effect after ceased metformin medication at delivery,